Influenza and Memory T Cells: How to Awake the Force
Identifieur interne : 000434 ( Main/Exploration ); précédent : 000433; suivant : 000435Influenza and Memory T Cells: How to Awake the Force
Auteurs : Jan Spitaels [Belgique] ; Kenny Roose [Belgique] ; Xavier Saelens [Belgique]Source :
- Vaccines [ 2076-393X ] ; 2016.
Abstract
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals. The past few years, the importance of cellular immunity, and especially memory T cells, in long-lived protection against influenza virus has become clear. To overcome the shortcomings of current influenza vaccines, eliciting both humoral and cellular immunity is imperative. Today, several new vaccines such as infection-permissive and recombinant T cell inducing vaccines, are being developed and show promising results. These vaccines will allow us to stay several steps ahead of the constantly evolving influenza virus.
Url:
DOI: 10.3390/vaccines4040033
PubMed: 27754364
PubMed Central: 5192353
Affiliations:
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Le document en format XML
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Flandre-Orientale</region></placeName></affiliation></author><author><name sortKey="Roose, Kenny" sort="Roose, Kenny" uniqKey="Roose K" first="Kenny" last="Roose">Kenny Roose</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author><author><name sortKey="Saelens, Xavier" sort="Saelens, Xavier" uniqKey="Saelens X" first="Xavier" last="Saelens">Xavier Saelens</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27754364</idno><idno 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xml:lang="en" level="a" type="main">Influenza and Memory T Cells: How to Awake the Force</title><author><name sortKey="Spitaels, Jan" sort="Spitaels, Jan" uniqKey="Spitaels J" first="Jan" last="Spitaels">Jan Spitaels</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author><author><name sortKey="Roose, Kenny" sort="Roose, Kenny" uniqKey="Roose K" first="Kenny" last="Roose">Kenny Roose</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author><author><name sortKey="Saelens, Xavier" sort="Saelens, Xavier" uniqKey="Saelens X" first="Xavier" last="Saelens">Xavier Saelens</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author></analytic><series><title level="j">Vaccines</title><idno type="eISSN">2076-393X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals. The past few years, the importance of cellular immunity, and especially memory T cells, in long-lived protection against influenza virus has become clear. To overcome the shortcomings of current influenza vaccines, eliciting both humoral and cellular immunity is imperative. Today, several new vaccines such as infection-permissive and recombinant T cell inducing vaccines, are being developed and show promising results. These vaccines will allow us to stay several steps ahead of the constantly evolving influenza virus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Palese, P" uniqKey="Palese P">P. 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Swain</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Province de Flandre-Orientale</li><li>Région flamande</li></region><settlement><li>Gand</li></settlement><orgName><li>Université de Gand</li></orgName></list><tree><country name="Belgique"><region name="Région flamande"><name sortKey="Spitaels, Jan" sort="Spitaels, Jan" uniqKey="Spitaels J" first="Jan" last="Spitaels">Jan Spitaels</name></region><name sortKey="Roose, Kenny" sort="Roose, Kenny" uniqKey="Roose K" first="Kenny" last="Roose">Kenny Roose</name><name sortKey="Saelens, Xavier" sort="Saelens, Xavier" uniqKey="Saelens X" first="Xavier" last="Saelens">Xavier Saelens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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